What does Almetamine do?

Almetamin is a product of Korea United Pharm INT'L Joint Stock Company. It has the main ingredients Dexchlorpheniramine maleate 2 mg and Betamethasone 0.25 mg. The drug is indicated in the treatment of some of the following cases: Urticaria, seasonal allergic rhinitis, allergic rhinitis, chronic bronchial asthma, drug hypersensitivity, contact dermatitis, atopic dermatitis , eczema, allergic conjunctivitis...

Almetamine medicine includes 2 main ingredients:
Betamethasone: 0.25mg Dexchlorpheniramine: 2mg

Indications
Almetamin is indicated for use in the following cases:
Urticaria Atopic dermatitis, contact dermatitis, eczema Chronic bronchial asthma Seasonal allergic rhinitis and allergic rhinitis Inflammation allergic conjunctiva. Pharmacokinetics Almetamine combines the anti-allergic and anti-inflammatory effects of corticosteroids betamethasone, a derivative of prednisolone, and the antihistamine action of dexchlorpheniramine maleate. Thanks to the combination of betamethasone and dexchlorpheniramine maleate, the reduction of corticosteroid dose is still similar to the effect of corticosteroids alone at higher doses.
Pharmacokinetics
Dexchlorpheniramine maleate: Dexchlorpheniramine maleate is absorbed relatively slowly after administration. Its concentration peaks in plasma after 2.5 to 6 hours. Bioavailability of the drug is low with reported values ​​of 25 to 50%. Approximately 75% of circulating dexchlorpheniramine is close to plasma proteins. Dexchlorpheniramine maleate is distributed throughout the body, including by way of the CNS. Excreted in urine as unchanged drug and metabolites, only trace amounts in feces. There have been a number of studies that have demonstrated more and more rapid absorption in children. The clearance is faster in children and the half-life is shorter than in adults. Betamethasone: Well absorbed when taken orally. After absorption, approximately 90% or more of the plasma betamethasone is bound to proteins. Excretion: Via urine as metabolites.

How to take the medicine
Almetamin 0 25mg is used orally.
Dosage
For adults and children over 15 years old: The starting dose is 1 - 2 tablets x 3 - 4 times/day. For children 8-14 years old: The starting dose is 1⁄2 - 1 tablet/3 - 4 times/day. For children 3-7 years old: The starting dose is 1⁄4 tablets/2 - 3 times/day. When symptoms have improved, the patient can gradually reduce the dose to the minimum maintenance dose and then stop taking the drug. Dosage may be increased as directed by a physician.
Note: The above dosage is for reference only. The specific dose depends on the condition and the progression of the disease. You need to consult your doctor or medical professional to get the right dose.
What to do in case of drug overdose?
Some of the overdose reactions that occur with common antihistamines (sedation) may vary from central nervous system depression (sedation, apnea, decreased neurovigilance, cardiac arrest) pulse), to excitation (insomnia, hallucinations, tremors, convulsions) and even death.
Some other signs and symptoms include: ataxia, double vision and hypotension, dizziness, ringing in the ears.

When using Daehwa Almetamin, you may experience some unwanted effects (ADRs).
Urinary system: Polyuria, difficulty urinating. Cardiovascular system: High blood pressure. Hematology: Thrombocytopenia, leukocytosis. Skin: Eczema, acne, melasma, hirsutism, hair loss, itching and sweating disorder, subcutaneous hemorrhage, purpura. Hypersensitivity reactions: Rash. Psychiatric: Mental confusion, restlessness, agitation, insomnia, somnolence, headache, feeling of suffocation. Gastrointestinal: Peptic ulcer, heartburn, stomach pain, nausea, vomiting, mania, thirst, increased appetite and diarrhea. Endocrine: Menstrual disorders, acute adrenal insufficiency, diabetes and growth inhibition in children. Musculoskeletal: Osteoporosis, steroid myopathy, myalgia and arthralgia. Ophthalmology: Subcapsular cataracts and glaucoma. Other side effects: Infection, irritability, moon face, fever and weight gain. When experiencing side effects of the drug, the first thing to do is to stop using it. Then notify the doctor or go to the nearest medical facility for timely treatment.

Contraindications
Almetamin is contraindicated in some of the following cases:
People with eye disease, eg glaucoma. People with an enlarged prostate gland. People who have just been vaccinated against smallpox. Because when immunizing patients who are taking steroid hormones can lead to mental disorders and antigen-antibody reactions do not occur. Precautions for use
Users should not stop the drug suddenly, as some symptoms such as fever, headache, loss of appetite, weakness, muscle pain, joint pain and shock syndrome may occur. Therefore, users should stop taking the drug slowly.
Use Almetamine 2mg with caution in the following patient groups: Patients with tuberculosis, peptic ulcer, mental disorders, herpes conjunctivitis, high blood pressure, thrombosis, subcapsular cataract, diabetes, osteoporosis and infectious diseases.
Pregnancy
In animals, there have been studies of teratogenicity with Almetamine tablets. Infants whose mothers took adrenal hormones during pregnancy may have adrenal insufficiency. The safety of the drug during pregnancy has not been established. Therefore, Almetamine tablets should not be used by pregnant women. Except in cases where there is a doctor's prescription for taking the drug.
Lactation
Betamethasone is excreted in breast milk and may be harmful to a young child. Because the drug can inhibit growth and cause other undesirable effects such as decreased adrenal function. When using this drug, the benefit to the mother must be weighed against the potential harm to the infant.
Dexchlorpheniramine is excreted in human milk, side effects of antihistamine use have been described as having a higher risk in neonates and premature infants. The manufacturer has recommended that, due to the potential for serious adverse reactions in the nursing infant, a decision should be made whether to discontinue nursing or discontinue the drug. In addition, the importance of the drug to the mother should be considered.

In the case of taking this medicine with the following drugs may increase the effect of both drugs: Central nervous system depressants, MAO inhibitors and alcoholic beverages. Almetamin is a drug indicated for the treatment of allergic diseases with the main active ingredients being Betamethasone and Dexchlorpheniramine. To ensure the effectiveness of treatment and avoid side effects, patients need to strictly follow the instructions of the doctor or pharmacist.
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