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Perlecan Antibody (E-6): sc-377219
- Perlecan Antibody (E-6) is a mouse monoclonal IgG1 κ Perlecan antibody, cited in 11 publications, provided at 200 µg/ml
- raised against amino acids 4092-4391 mapping near the C-terminus of Perlecan of human origin
- Perlecan Antibody (E-6) is recommended for detection of Perlecan of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-Perlecan Antibody (E-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of Perlecan (E-6): sc-377219.
- m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Perlecan Antibody (E-6) for WB and IHC(P) applications. These reagents are now offered in bundles with Perlecan Antibody (E-6) (see ordering information below).
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Perlecan Antibody (E-6) is an IgG1 κ mouse monoclonal Perlecan antibody (also designated HSPG2 antibody, Schwartz-Jampel syndrome 1 (chondrodystrophic myotonia) antibody, SJS antibody, SJS1 antibody, HSPG antibody, PLC antibody, or PRCAN antibody) that detects the Perlecan protein of human origin by WB, IP, IF, IHC(P) and ELISA. Perlecan Antibody (E-6) is available as both the non-conjugated anti-Perlecan antibody form, as well as multiple conjugated forms of anti-Perlecan antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Perlecan is part of a large family of heparan sulfate proteoglycans (HSPGs). As key components of cell surfaces and extracellular matrices, HSPGs modulate growth factor activities and thereby influence cell growth and differentiation. Additionally, HSPGs play a critical role in regulating tumor cell metastasis by mediating cell adhesion and the activities of growth and angiogenic factors. Perlecan consists of five distinct structural domains that interact with a number of matrix molecules, cytokines and growth factors to influence cartilage development and neuromuscular junction activity. Antithrombin, a key regulator of blood coagulation proteases, and TGFb1 act as inhibitors and stimulators of Perlecan expression, respectively, interactions which may provide avenues for therapeutic intervention in certain types of cancer.
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