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Butalbital / Acetaminophen Coupon - Butalbital / Acetaminophen 50mg/325mg tablet
Specialty Drug

butalbital / acetaminophen

Generic Marten
Used for Tension Headache
Used for Tension Headache

Bupap (butalbital / acetaminophen) is a combination medication containing butalbital and acetaminophen that can help treat and relieve pain from tension headaches. The medication is not a first-choice option for headaches, since it can lead to worsening headaches if it's used too often.

Reviewed by:
reviewer
Cydnee Ng, PharmD
reviewer
Ashley Wong, PharmD
Last reviewed on July 29, 2021
BasicsWarningsSide effectsPros & consPharmacist tipsFAQsDosageInteractionsCostContraindicationsAlternativesLatest newsImagesPricesMedicare
basics-icon

What is Bupap (butalbital / acetaminophen)?

What is Bupap (butalbital / acetaminophen) used for?

  • Tension headaches

How Bupap (butalbital / acetaminophen) works

Bupap (butalbital / acetaminophen) is a combination of two medications that help relieve different aspects of tension headaches. Tension headaches are commonly related to stress or anxiety, and they can cause pain.

  • Butalbital is a barbiturate, which is a type of medication that lowers anxiety and helps you relax.

  • Acetaminophen is a pain reliever. It's unclear how exactly acetaminophen works, but it's thought to work on many chemical pathways in the body to change how we respond to pain.

Are you looking for information on Fioricet (butalbital / acetaminophen / caffeine) or Fioricet with Codeine (butalbital / acetaminophen / caffeine / codeine) instead?

Drug Facts

Common BrandsBupap, Allzital, Tencon
Drug ClassBarbiturate / Analgesic
Controlled Substance ClassificationControlled in some states. See FAQs below.
Generic StatusLower-cost generic available
AvailabilityPrescription only
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What are the side effects of Bupap (butalbital / acetaminophen)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Sleepiness
  • Lightheadedness
  • Dizziness
  • Shortness of breath
  • Nausea
  • Vomiting
  • Stomach pain
  • Lack of coordination and alertness

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Overdose: Not responding to sound or touch, extreme sleepiness, slowed breathing, confusion, stomach pain, dark urine, yellowing of your skin or eyes, sweating
  • Withdrawal: Seizures, delusions, restlessness, trouble sleeping, shakiness
  • Serious skin reactions: Reddening or peeling of the skin, painful rash, fluid-filled blisters
  • Serious allergic reactions: Trouble breathing, itchiness, swelling of the face, mouth, or throat

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

Bleeding or crusting sores on lips

chest pain

fever with or without chills

hive-like swellings (large) on eyelids, face, lips, and/or tongue

muscle cramps or pain

red, thickened, or scaly skin

shortness of breath, troubled breathing, tightness in chest, or wheezing

skin rash, itching, or hives

sores, ulcers, or white spots in mouth (painful)

Symptoms of overdose

Anxiety, confusion, excitement, irritability, nervousness, restlessness, or trouble in sleeping (severe, especially with products containing caffeine)

convulsions (seizures) (for products containing caffeine)

diarrhea, especially if occurring together with increased sweating, loss of appetite, and stomach cramps or pain

dizziness, lightheadedness, drowsiness, or weakness, (severe)

frequent urination (for products containing caffeine)

hallucinations (seeing, hearing, or feeling things that are not there)

increased sensitivity to touch or pain (for products containing caffeine)

muscle trembling or twitching (for products containing caffeine)

nausea or vomiting, sometimes with blood

ringing or other sounds in ears (for products containing caffeine)

seeing flashes of "zig-zag" lights (for products containing caffeine)

shortness of breath or unusually slow or troubled breathing

slow, fast, or irregular heartbeat

slurred speech

staggering

swelling, pain, or tenderness in the upper abdomen or stomach area

unusual movements of the eyes

Check with your doctor as soon as possible if any of the following side effects occur:

Less common

Confusion (mild)

mental depression

unusual excitement (mild)

Rare

Bloody or black, tarry stools

bloody urine

pinpoint red spots on skin

swollen or painful glands

unusual bleeding or bruising

unusual tiredness or weakness (mild

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Bloated or "gassy" feeling

dizziness or lightheadedness (mild)

drowsiness (mild)

nausea, vomiting, or stomach pain (occurring without other symptoms of overdose)

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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pros-and-cons

Pros and cons of Bupap (butalbital / acetaminophen)

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Pros

Combines two medications into a single pill to relieve headache pain in different ways

Lower risk of stomach problems, constipation, or bleeding compared to other butalbital headache medications that contain aspirin or codeine

Available as a lower-cost, generic medication

thumbs-down

Cons

Taking Bupap (butalbital / acetaminophen) for a long period of time can become habit-forming.

Not recommended as a first-choice option for headaches because of risk of worsening headaches with overuse or frequent medication use

Can cause bothersome symptoms if stopped suddenly after taking for a long period of time

Is a controlled medication in some states, so it might have special requirements to getting your prescription filled

pharmacist-tips

Pharmacist tips for Bupap (butalbital / acetaminophen)

pharmacist

  • Bupap (butalbital / acetaminophen) can make you feel sleepy. Make sure you know how the medication affects you before driving a car or doing activities that require you to concentrate.

    • It's not recommended to drink alcohol or take other medications that make you feel sleepy or less alert while taking Bupap (butalbital / acetaminophen). This can raise your risk of extreme sleepiness and accidental injuries. Drinking alcohol with Bupap (butalbital / acetaminophen) can also raise your risk of liver damage.

      • Don't take other medications that contain acetaminophen (Tylenol) while taking Bupap (butalbital / acetaminophen). Taking high amounts of acetaminophen (Tylenol) can raise your risk of liver damage. Don't take more than 3 to 4 grams of acetaminophen per day. Ask your provider what your maximum daily amount of acetaminophen is, since this depends on your provider's instructions.

        • Bupap (butalbital / acetaminophen) can be habit-forming. Don't take the medication more often than prescribed, for longer than prescribed, or at higher doses than prescribed. If you're taking the medication for a long period of time, you might start to feel the need to take higher doses to get the same relief. You can also experience bothersome side effects, such as seizures, delusions, restlessness, trouble sleeping, and shakiness, if you stop taking the medication suddenly.

          faqs

          Frequently asked questions about Bupap (butalbital / acetaminophen)

          What makes Bupap (butalbital / acetaminophen) a controlled medication in some states?
          Bupap (butalbital / acetaminophen) is a controlled medication in some states, because it contains butalbital. Because butalbital can make people feel relaxed, there's a risk of misuse, meaning people might take the medication for a different reason or in a different way than it's prescribed. Taking butalbital for a long time can also cause physical dependence, where more medication is needed to get the same relaxed feeling. Physical dependence can lead to serious withdrawal symptoms if you lower the dose too quickly or if you stop the medication suddenly. These symptoms include seizures, delusions, restlessness, trouble sleeping, and shakiness. Because of these dangerous risks with butalbital use, some state governments place strict regulations on Bupap (butalbital / acetaminophen) to lower the risk of misuse, dependence, and related consequences.
          Why is Bupap (butalbital / acetaminophen) a controlled medication in some states and not others?
          State laws can differ when categorizing Bupap (butalbital / acetaminophen) as a controlled medication. In some states, whether Bupap (butalbital / acetaminophen) is controlled or not depends on how much butalbital it contains compared to other ingredients and how likely the medication can cause the dangerous risk of misuse and dependence. In other states, Bupap (butalbital / acetaminophen) is categorized as a controlled medication solely based on the fact that butalbital alone is a controlled medication.
          What does it mean for me if Bupap (butalbital / acetaminophen) is a controlled medication in my state?
          If Bupap (butalbital / acetaminophen) is a controlled medication in your state, it means that your state government places strict regulations on the medication. These regulations can include how much Bupap (butalbital / acetaminophen) your pharmacy can order, when your prescription expires, how many tablets that can be prescribed over a given period of time, and how many times you can get it refilled. The regulations that the government places on Bupap (butalbital / acetaminophen) helps ensure you're taking the medication safely and responsibly.
          What's the difference between Bupap (butalbital / acetaminophen) and Fioricet (butalbital / acetaminophen / caffeine)?
          Bupap (butalbital / acetaminophen) and Fioricet (butalbital / acetaminophen / caffeine) are both combination medications containing butalbital and acetaminophen that are used to treat tension headaches. Though they are used to treat the same pain condition and have similar ingredients, Fioricet also contains caffeine, which is thought to boost the pain-relieving activity of acetaminophen.
          Can you take Bupap (butalbital / acetaminophen) if you're pregnant or breastfeeding?
          Bupap (butalbital / acetaminophen) is not recommended if you're pregnant or breastfeeding. Taking Bupap (butalbital / acetaminophen) for a long period of time during pregnancy might cause neonatal abstinence syndrome. This is a condition where your unborn baby becomes dependent on butalbital while in the womb, since butalbital can be passed to your unborn baby during pregnancy. Once your baby is born, they might experience withdrawal symptoms similar to as if you were stopping the medication suddenly. These symptoms can include seizures, body shakes, high-pitched crying, and poor feeding or sucking behaviors. Butalbital can also be found in breast milk, and it might raise the risk of poor feeding behaviors, tiredness, vomiting, sleepiness and slow reflexes in your baby. If you're pregnant or breastfeeding, talk to your healthcare provider about the risks and benefits of taking Bupap (butalbital / acetaminophen) and to see if there are safer headache medications for you and your baby.
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          What are the risks and warnings for Bupap (butalbital / acetaminophen)?

          Bupap (butalbital / acetaminophen) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

          risk-warning

          Liver damage

          • Risk factors: History of liver disease | Taking other medications containing acetaminophen (Tylenol) | Taking more than 3 to 4 grams of acetaminophen (Tylenol) in a day | Alcohol use

            Bupap (butalbital / acetaminophen) contains acetaminophen. Taking more than 3 to 4 grams of acetaminophen (Tylenol) in a day raises your risk of serious liver damage. Because some over-the-counter medications for fever, pain, cold, or flu symptoms contain acetaminophen (Tylenol), it's important to be aware of how much acetaminophen (Tylenol) you're taking throughout the day. To lower this risk, don't take more than one medication containing acetaminophen (Tylenol). If you realize you've taken more than 3 to 4 grams of acetaminophen (Tylenol) in a day, go to the emergency room right away even if you feel well. If you notice symptoms of liver damage, like stomach pain, dark urine, yellowing of your skin or eyes, get medical help as soon as possible.

            risk-warning

            Difficulty concentrating

            • Risk factors: Taking Bupap (butalbital / acetaminophen) with alcohol | Taking other medications that make you less alert | Age 65 years or older

              Bupap (butalbital / acetaminophen) can affect your ability to focus, think, and react. Taking other medications that make you feel sleepy and less alert can worsen these symptoms. Avoid activities that need you to focus, like driving a car or operating machinery, until you know how this medication affects you.

              risk-warning

              Misuse, dependence, and withdrawal

              • Risk factors: Taking Bupap (butalbital / acetaminophen) longer than prescribed | Taking higher doses of Bupap (butalbital / acetaminophen) than prescribed | Taking Bupap (butalbital / acetaminophen) more often than prescribed

                Bupap (butalbital / acetaminophen) contains butalbital, which can be habit-forming. It can cause physical dependence if it's taken for a long time, meaning you might need higher doses of the medication to get the same relief. It can also cause withdrawal symptoms, like seizures, restlessness, trouble sleeping, and shakiness, if you lower your dose or stop taking the medication suddenly. To lower the risk of physical dependence, don't take Bupap (butalbital / acetaminophen) longer than prescribed, at higher doses than prescribed, or more often than prescribed. If you no longer want to take Bupap (butalbital / acetaminophen), talk to your healthcare provider so they can instruct you on how to stop taking the medication safely. Talk to your healthcare provider about alternative treatments if you have concerns about taking Bupap (butalbital / acetaminophen).

                risk-warning

                Severe skin reactions

                Bupap (butalbital / acetaminophen) contains acetaminophen, which can cause rare but serious, life-threatening skin reactions. These reactions can look like reddening or peeling of the skin, painful rash, and fluid-filled blisters. If you notice any of these symptoms, stop taking Bupap (butalbital / acetaminophen) and go to the emergency room right away.

                risk-warning

                Severe allergic reaction

                Bupap (butalbital / acetaminophen) contains acetaminophen, which have caused severe allergic reactions in some people. Bupap (butalbital / acetaminophen) shouldn't be used if you've had a severe allergic reaction to acetaminophen in the past. If you experience trouble breathing, itchiness, or swelling of the face, mouth, or throat, go to the emergency room right away.

                dosage

                Bupap (butalbital / acetaminophen) dosage forms

                tablet
                Tablet
                DosageAs low as
                50mg/300mg$47.88 for 30 tablets
                25mg/325mg$250.85 for 60 tablets
                50mg/325mg$15.07 for 30 tablets

                Typical dosing for Bupap (butalbital / acetaminophen)

                • Tablets containing 25 mg/325 mg (butalbital/acetaminophen): The typical dose is 2 tablets by mouth every 4 hours. Don't take more than 12 tablets in a day.

                • Tablets containing 50 mg/300 mg or 50 mg/325 mg (butalbital/acetaminophen): The typical dose is 1 to 2 tablets by mouth every 4 hours as needed for headache relief. Don't take more than 6 tablets in a day.

                interactions

                Interactions between Bupap (butalbital / acetaminophen) and other drugs

                Bupap (butalbital / acetaminophen) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Bupap (butalbital / acetaminophen). Please note that only the generic name of each medication is listed below.

                Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

                Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take.

                • Riociguat
                • Viloxazine

                Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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                How much does Bupap (butalbital / acetaminophen) cost?

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                Bupap (butalbital / acetaminophen) (generic)
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                contraindications-icon

                Bupap (butalbital / acetaminophen) contraindications

                Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Bupap (butalbital / acetaminophen) will not be safe for you to take.

                • Porphyria (a condition that affects your skin and nerves)

                alternatives

                What are alternatives to Bupap (butalbital / acetaminophen)?

                There are a number of medications that your doctor can prescribe in place of Bupap (butalbital / acetaminophen). Compare a few possible alternatives below.
                Bupap (butalbital / acetaminophen)
                Used for:

                • Tension headaches

                $15.07 Lowest GoodRx priceView Prices
                Fioricet
                Used for:

                • Tension headaches

                $11.91 Lowest GoodRx priceView Prices
                Butalbital/aspirin/caffeine
                Used for:

                • Tension headaches

                $14.44 Lowest GoodRx priceView Prices
                images

                Bupap (butalbital / acetaminophen) images

                White Oblong Mia 106 - Butalbital/Acetaminophen 50mg-325mg Tablet
                This medicine is White, Oblong, Scored Tablet Imprinted With "Mia 106".White Oblong Mia 106 - Butalbital/Acetaminophen 50mg-325mg Tablet

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