Orji`s presentation actin filament
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This presentation is done by Orji Jonathan Orji with the guidance of Tamriko valishvili, Associate Prof. Doctor of medicine. Is very educative, well organized and a good learning material, enjoy it to the fullness. Comment, like and share if you fine it useful.
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Orji`s presentation actin filament
- 1. ORJI JONATHAN ORJI MD, phD Kutaisi 2013 ACTIN FILAMENT
- 2. Actin filaments are thin and flexible 7 nm in diameter Less rigid than microtubules Plus end - fast growing Minus end - slow growing Monomers polymerize into a helical chain
- 3. Actin and microtubules polymerize using similar mechanisms Monomeric actin binds to ATP Upon polymerization, actin ATPase activity cleaves ATP to ADP ATP hydrolysis acts as a molecular “clock” Older actin filaments with ADP are unstable and disassemble
- 4. Myosins are actin-based motor proteins Myosins convert ATP hydrolysis into movement along actin filaments Many different classes of myosins (>30 in humans) Some myosins move cargoes, other myosins slide actin (as in muscles) Actin & ATP binding sites in N-terminal head domain
- 5. Contraction is activated by calcium release from the sarcoplasmic reticulum
- 6. Contraction is regulated by a Ca+2- mediated change in the conformation of troponin
- 7. Contraction is regulated by a Ca+2- mediated change in the conformation of troponin