X-Neu5Ac (X-Sialic acid, X-NANA)

Product Description

X-Neu5Ac (X-Sialic acid, X-NANA)
Catalog number: MDP0878
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 537.74 g/mol
Supplied as: ~ 5 mg/mL Solution
Applications: histochemical substrate for neuraminidase
Storage: -20°C
Keywords: 5-Bromo-4-Chloroindol-3-yl-5-Acetamido-3,5-Dideoxy-alpha-D-Glycero-D-Galacto-2-Nonulopyranosidonic Acid, X-Sialic acid, X-NANA
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.
Indication for Use:This product is for Research Use Only. This product is NOT for human or animal use.

References:
1: Fujii I, Iwabuchi Y, Teshima T, Shiba T, Kikuchi M. X-Neu5Ac: a novel
substrate for chromogenic assay of neuraminidase activity in bacterial
expression systems. Bioorg Med Chem. 1993 Aug;1(2):147-9.

2: Kerr CL, Hanna WF, Shaper JH, Wright WW. Lewis X-containing glycans are
specific and potent competitive inhibitors of the binding of ZP3 to
complementary sites on capacitated, acrosome-intact mouse sperm. Biol Reprod.
2004 Sep;71(3):770-7.

3: Hirota K, Kanitani H, Nemoto K, Ono T, Miyake Y. Cross-reactivity between
human sialyl Lewis(x) oligosaccharide and common causative oral bacteria of
infective endocarditis. FEMS Immunol Med Microbiol. 1995 Oct;12(2):159-64.

4: Minami A, Shimizu H, Meguro Y, Shibata N, Kanazawa H, Ikeda K, Suzuki T.
Imaging of sialidase activity in rat brain sections by a highly sensitive
fluorescent histochemical method. Neuroimage. 2011 Sep 1;58(1):34-40.

5: Saito M, Hagita H, Iwabuchi Y, Fujii I, Ikeda K, Ito M. Fluorescent
cytochemical detection of sialidase activity using 5-bromo-4-chloroindol-3-yl-
alpha- D- N-acetylneuraminic acid as the substrate. Histochem Cell Biol. 2002
May;117(5):453-8.

6: Minami A, Meguro Y, Ishibashi S, Ishii A, Shiratori M, Sai S, Horii Y,
Shimizu H, Fukumoto H, Shimba S, Taguchi R, Takahashi T, Otsubo T, Ikeda K,
Suzuki T. Rapid regulation of sialidase activity in response to neural activity
and sialic acid removal during memory processing in rat hippocampus. J Biol
Chem. 2017 Apr 7;292(14):5645-5654.

7: Saito M, Hagita H, Ito M, Ando S, Yu RK. Age-dependent reduction in sialidase
activity of nuclear membranes from mouse brain. Exp Gerontol. 2002
Jul;37(7):937-41.

8: Berg EL, Magnani J, Warnock RA, Robinson MK, Butcher EC. Comparison of
L-selectin and E-selectin ligand specificities: the L-selectin can bind the
E-selectin ligands sialyl Le(x) and sialyl Le(a). Biochem Biophys Res Commun.
1992 Apr 30;184(2):1048-55.

9: Horie K, Sakagami M, Kuramochi K, Hanasaki K, Hamana H, Ito T. Enhanced
accumulation of sialyl Lewis X-carboxymethylpullulan conjugate in acute
inflammatory lesion. Pharm Res. 1999 Feb;16(2):314-20.
10: Kogan TP, Revelle BM, Tapp S, Scott D, Beck PJ. A single amino acid residue
can determine the ligand specificity of E-selectin. J Biol Chem. 1995 Jun
9;270(23):14047-55.

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